Background: There is growing literature on mental health literacy (MHL), but few studies have conducted research on anything more than demographic predictors of MHL. We believe that those who are more empathic would be more interested in and more knowledgeable about mental illnesses. Objective: This study was concerned to establish whether people who were more empathic would have higher MHL. Methods: The 129 volunteer, university panel, participants completed the Interpersonal Reactivity Index and were presented with 15 vignettes describing people with various mental disorders. Questions assessed participants' identification of the disorders and their perception of the life adjustment of each person. Key Results: The results showed that 3 of the 4 empathy subscales correlated with the MHL score. Results from correlation and regression analyses suggest that people who are more empathic, have studied psychology, and have had personal experience of mental illness demonstrate better MHL. Conclusions: As predicted, people with greater MHL had greater empathy, but this cross-sectional correlational study could not ascertain causal patterns. [ Health Literacy Research and Practice. 2017;1(2):e31–e40.] Plain Language Summary: This study addressed whether people who are more empathic tend to be better informed about mental health issues because of their care for, interest in, and sympathy toward those with a range of mental illnesses. This was a questionnaire study and we did indeed find the relationship we thought may occur. However, we cannot be certain which caused which—do those who know more about mental illnesses and how common they are become more empathic or do those with greater empathy learn more about all aspects of mental illness?