Objective The aim of this study was first to demonstrate that a combination of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol could synergize in vitro on biological pathways associated with hair growth and then to demonstrate the benefit on hair density in a clinical study. Methods The effects of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol directly on the hypoxic inducible factor‐1α protein (HIF‐1α) and related genes expression were demonstrated on keratinocytes in culture in vitro using western‐blot analysis and real time quantitative polymerase chain reaction analysis. The effect of resveratrol against oxidative stress induced by hydrogen peroxide treatment was studied in hair follicle and hair matrix cells in vitro using the sensitive probe Dichloro‐dihydro‐fluorescein diacetate (DCFH‐DA). Finally, a randomized clinical study on hair density was conducted on 79 Caucasian female subjects to assess the effect of this combination of actives. Results Pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol stabilized HIF‐1a protein and increased the expression of HIF‐1α target genes. Resveratrol significantly reduced the oxygen peroxide‐induced oxidative stress generated in hair follicle and hair matrix cells. The clinical study showed that a topical treatment with the combination significantly increased the hair density on women from 1.5 months. Conclusion In addition to the antioxidant properties of resveratrol, the association of pyridine‐2, 4‐dicarboxylic acid diethyl ester and resveratrol revealed a synergistic effect on the HIF‐1α pathway. The results of the clinical study confirmed the importance of such a combination to increase the hair density.

In March 2020, the World Health Organization declared the disease caused by SARS-CoV-2 coronavirus “pandemic.” To reduce the risk of contamination, many countries have ordered a lockdown characterized by social distancing and restrictive isolation measures. While the lockdown has proven to be quite effective in terms of physical health, little is known about its impact on couple satisfaction in a dyadic perspective. The current research was a 4-waves longitudinal study (i.e., from March to July 2020) with the objective to examine the trajectory of couple satisfaction during the lockdown with a dyadic perspective (N = 108 couples), including the presence (or absence) of children at home, the number of hours spent together, and the duration of the relationship as time-invariant predictors and the partner’s couple satisfaction trajectory as a time-varying covariate. Results showed positive intraindividual changes in couple satisfaction during the lockdown, especially an increase in partners’ effectiveness for resolving couple conflicts and a decrease in partners’ aggressiveness. Partners had also perceived the influence of the lockdown as more and more positive over time on couple and family functioning. Finally, the couple satisfaction of both partners changed in tandem during the lockdown: The perception of the couple relationship seems to similarly evolve between partners.

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In March 2020, the disease caused by SARS-CoV-2 coronavirus has been declared a “pandemic” by the World Health Organization. To reduce the risk of contamination, many countries have ordered a strict lockdown characterized by social distancing and restrictive isolation measures. This pandemic has profoundly affected couples’ daily lives. The objective of our three-wave longitudinal study (N = 229) was to examine the trajectory of couple satisfaction during 1 year of COVID-19 pandemic and lockdown, with dyadic coping as a predictor of the intraindividual change. Our results showed that couple satisfaction remained stable over time. Dyadic coping was also found to be a predictor of intraindividual changes in partners’ Relationship Dissatisfaction and Difficulties in Problem-solving Communication during the pandemic: Relationship Dissatisfaction increased over time when dyadic coping was weak, while Difficulties in Problem-solving Communication decreased over time when dyadic coping was high. The discussion underlined the importance of focusing couple interventions on dyadic coping during stressful situations, like the COVID-19 pandemic.

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