Weed management in the pre-transplantation of coffee plants is an essential condition for the future success of the crop. Currently, the producer has few options to perform chemical management at this stage. Therefore, one of the solutions that is being used is the tank mixing of products proven efficient with new products on the market, such as indaziflam. The objective of this study is to know the selectivity of indaziflam, associated or not with oxyfluorfen, in coffee pre-planting and its effectiveness in weed control. Thus, the following treatments were tested in the field: indaziflam (25 g ha^-1 a.i.), indaziflam (50 g ha^-1 a.i.), oxyfluorfen (960 g ha^-1 a.i.), indaziflam (25 g ha^-1 a.i.) + oxyfluorfen (960 g ha^-1 a.i.), indaziflam (50 g ha^-1 a.i.) + oxyfluorfen (960 g ha^-1 a.i.), plus a weeded and a non-weeded control. All treatments caused low intoxication in the seedlings, but without impairing the development and orphological variables of the plants. The treatments were efficient in controlling the species <em>Bidens pilosa L</em>., <em>Commelina benghalensis</em> L., <em>Urochloa decumbens</em>, <em>Emilia fosbergii</em> and <em>Melampodium perfoliatum</em> until 68 days after application. At 104 days, it was observed that there was a reduction in the efficiency of the products. It is concluded that the associated use of indaziflam and oxyfluorfen does not cause intoxications capable of interfering with the development of coffee plants. The association of these herbicides or their isolated applications is efficient in the control of weeds in the pre-transplantation of coffee plants, and the choice of the best management strategy is dependent on the weed community present in each area.