Increased intraabdominal pressure (IAP) during laparoscopy can reduce venous return, but changes in respiratory system mechanics and their effect in left cardiac function are not well documented. This study evaluated the effects of different IAPs on respiratory mechanics and cardiac function in 10 healthy nonpregnant adult Santa Ines ewes randomly submitted to a crossover study using different IAPs: 0 mm Hg (G1), 10 mm Hg (G2), 12 mmHg (G3), and 15 mmHg (G4). Animals were anesthetized and mechanically ventilated (VT = 15 ml/kg; positive end‐expiratory pressure = 3 cmH2O; FiO2 = 1.0). Pneumoperitoneum was induced by Hasson's trocar cannula. Variables were measured at INITIAL (IAP, 0 mmHg) and FINAL time points for each IAP after 1 h. At FINAL, driving airway pressure (ΔP,RS), and percentage fraction of dead space (Vd/Vt) were higher in G3 and G4 than G1 (p = 0.002, difference in means [MD] 4.60, 95% CI: 7.91–1.28, and p < 0.001, MD 5.4, 95% CI: 8.7–2.0; p = 0.016, MD −9.5, 95% CI: −17.9 to −1.2; and p = 0.027, MD −8.7, 95% CI: −17.1 to −0.4). The ejection fraction and fractional shortening were lower in G3 (p = 0.039, MD −11.38, 95% CI: −0.07−−22.68; p = 0.015, MD −13.05, 95% CI: −1.74−−24.36) and G4 (p = 0.039, MD −9.94, 95% CI: −0.07 to −19.80; p = 0.015, MD −11.43, 95%CI: −1.57 to −21.30, respectively) than G2. In G3, the maximum pulmonary flow velocity correlated negatively with ΔP,RS (r = −0.740; p = 0.018), and Vd/Vt correlated positively with ΔP,RS (r = 0.738, p = 0.046). At IAP of 12 and 15 mm Hg impaired respiratory system mechanics, reduced left cardiac function and no change in maximum pulmonary artery flow velocity were detected. Therefore, respiratory mechanics should be monitored as an interplay to reduce left cardiac function.