Hindered ethers represent an underexplored area of chemical space due to the difficulty and inoperability associated with conventional reactions, despite the high-value of such structural motifs in a variety of societal applications 1-2. For example, such motifs are highly coveted in medicinal chemistry, as extensive substitution about the ether bond prevents unwanted metabolic processes that can lead to rapid in vivo degradation. Demonstrated herein is an exceptionally simple solution to this problem that leverages the power of electrochemical oxidation to liberate *

Saturated bioisosteres for ortho- and meta-substituted benzenes remain a current challenge for chemists.