Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with cognitive deterioration affecting day to day living and behavioural activities. It is commonest cause of senile and pre-senile dementia. In Alzheimer’s disease, a peptide referred as amyloid beta aggregates (oligomers), and accumulates in the brain to form deposits called as amyloid plaques. According to the world health organization (WHO), 5% of men and 6% of women of above 60 years are victims with Alzheimer’s type dementia globally. In India prevalence of dementia is 33.6%, of which AD contributes approximately 54% and vascular dementia constitutes approximately 39%. Patients with the prolonged use of some Non-steroidal anti-inflammatory (NSAID) drugs such as ibuprofen have lower risk of developing the symptoms of AD; however the chronic use of NSAID can produce a toxic effect on the kidney, liver and GI tract. Recent studies have demonstrated that a curcumin delivery system based on nanoscience and nanotechnology increases the therapeutic potential of this compound. Specifically, several nano-sized carriers such as phospholipid vesicles (liposomes), micelles, solid lipid nanoparticles, polymeric nanoparticles, emulsions, proteins and other molecular complexes have been developed for the efficient delivery of curcumin. Nano particles have demonstrated the enhanced Bioavailability of curcumin including circulation time in the blood. Various nano technology drug delivery system of curcumin showed increased Bio accessibility during treatment of Alzheimer’s disease.
Since last year of December 2019, a virus has been identifying in china’s city of Wuhan, virus name Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2). 2019 Novel Coronavirus (COVID-19) Disease is a very scary Disease. This disease is a challenge for Human for cure. These virus are effected all over the world’s country like America, Brazil, Turkey, China, Italy, Iran, India, Canada Russia etc., this virus first time reported in relation to the Huainan Seafood Wholesale Market (South China Seafood City Food Market) in Wuhan, China. This market gained media attention after being identified as a point of origin of the 2019–20 coronavirus pandemic. This virus have the common sign & symptoms like pneumonia and show symptoms of fever, headache, joint pain, Common cold, chills, shortness of breath, cough severe pneumonia, dyspnea, renal insufficiency. The detection of 2019- SCoV-like viruses in tiny size, live wild mammals in a market indicates a route of inters species spreading, although the natural loch is not known. This theory assembles a study of the molecular biology fundamental of these infectious agents, with particular prominence on the nature and identify of viral receptors, viral RNA synthesis, and the molecular interactions governing viral assembly.
Background: The outbreak of the novel coronavirus, COVID-19, has been declared a pandemic by the WHO on March 11th of 2020. Novel Coronavirus infection mediated pandemic started in China in December 2019 and is still killing 1000s of people throughout the world. The second most populous country, India too is fighting against this infectious disease. The country is taking effective measures to curb the pandemic by exerting extensive campaigning on sanitation and strict social distancing measures to quell the explosion of the infection rate. Treatment: No drugs are currently approved for Coronavirus Disease-2019 (COVID-19), although some have been tried. In view of recent studies and discussion on tested drugs on COVID-19 patients of India, I aimed to review existing literature and relevant websites regarding these drugs used in India including allopathic, plasma therapy,Ayurvedic and homeopathic medication.
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