Increasing emergence of drug-resistant bacteria is becoming a major problem globally. A retrospective study of 790 culture and sensitivity reports on microbial isolates, from infected wounds was carried out in KPC Medical College and Hospital, Jadavpur, Kolkata, India. 504 patients were males and 286 females. Gram negative organisms were isolated in 561 and gram positive in 229. Among the gram negative organisms, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli were the most common, whereas Staph aureus was the only gram positive organism isolated. Antibiotic sensitivity tests revealed most gram negative organisms susceptible to carbapenems, polymyxin and colistin. Staphylococci showed sensitivity to tigecycline, clindamycin, vancomycin, teicoplanin and linezolid. Interesting differences in the type of organisms isolated in male and female patients were noted. For example Enterococcus faecalis was found only in female patients. Increasing resistance of microorganisms cultured from infected wounds to first line and even second line antibiotics is a matter of great concern and can be attributed to indiscriminate and irrational use of broad spectrum antibiotics. This has to stop forthwith if we want to prevent resistance to antibiotics; otherwise morbidity, mortality and health care costs in treating patients with wound infections are going to increase exponentially

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