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In an earlier paper (Guyer and CIaus, '32) the authors showed that transplanted rat carcinoma after a period of growth in a susceptible animal induces a vacuolation of the basophile cells of the anterior pituitary gland that is indistinguishable from that wliicli follows castration. Furthermore, a subsequent study ('34) failed to reveal any characteristic differences in the Golgi apparatus of these two types of cells-an observation deriving its significance from the fact that the vacuolar substance appears t o arise as a secretion within the Golgi framcwork or to be transformed by it. Inasmuch as thyroidectomy is also followed by the formation of vacuoles in pituitary cells it became of interest to compare the two series of results. A careful cytological study of the basophile cells in the anterior hypophyses of many cxperimental animals has convinced them that the racuolation caused by thyroidectomy is of a different type from that which follows castration. A brief report was made on this material at the annual meeting of the American Association of Anatomists in April, 1935 (Abstract, Anat. Rec., vol. 61, 110. 4, Supplement, p. 21). li'urther study of the original material, together with that of additional sections from numerous castrated and cancerous animals is reported in the present 'This investigation was supported in part by a.

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