No abstract

Functional magnetic resonance imaging (fMRI) has become an important tool in Neuroscience due to its noninvasive and high spatial resolution properties compared to other methods like PET or EEG. Characterization of the neural connectivity has been the aim of several cognitive researches, as the interactions among cortical areas lie at the heart of many brain dysfunctions and mental disorders. Several methods like correlation analysis, structural equation modeling, and dynamic causal models have been proposed to quantify connectivity strength. An important concept related to connectivity modeling is Granger causality, which is one of the most popular definitions for the measure of directional dependence between time series. In this article, we propose the application of the partial directed coherence (PDC) for the connectivity analysis of multisubject fMRI data using multivariate bootstrap. PDC is a frequency domain counterpart of Granger causality and has become a very prominent tool in EEG studies. The achieved frequency decomposition of connectivity is useful in separating interactions from neural modules from those originating in scanner noise, breath, and heart beating. Real fMRI dataset of six subjects executing a language processing protocol was used for the analysis of connectivity.

Additional figures may be found at http://mariwork.iq.usp.br/dvar/.

Vector autoregressive (VAR) modelling is one of the most popular approaches in multivariate time series analysis. The parameters interpretation is simple, and provide an intuitive identification of relationships and Granger causality among time series. However, the VAR modelling requires stationarity conditions which could not be valid in many practical applications. Locally stationary or time dependent modelling seem attractive generalizations, and several univariate approaches have already been proposed. In this paper we propose an estimation procedure for time-varying vector autoregressive processes, based on wavelet expansions of autoregressive coefficients. The asymptotic properties of the estimator are derived and illustrated by computer intensive simulations. We also present an application to brain connectivity identification using functional magnetic resonance imaging (fMRI) datasets.

No abstract