Small cell carcinoma of the prostate is a rare neoplasm, with only a few series hitherto reported. A little less than half of the cases are associated with conventional acinar adenocarcinoma, which are usually high grade. Although consensus has not been reached, the majority of patients with small cell neuroendocrine carcinoma of the prostate have advanced disease at diagnosis and disproportionally low PSA levels compared to patients with conventional acinar adenocarcinoma. Treatment consists mainly of chemotherapy associated with surgery. Radiation therapy is reserved for selected cases. This study reviews the most up-to-date information on small cell carcinomas of the prostate.

IgA nephropathy (IgAN) is th e commonest primary glomerular disease worldwide. Studies on its prevalence in Brazil are however scarce. Databases and clinical records from 10 reference centres were retrospectively reviewed. Clinical and laboratory features at the moment of the biopsy were retrieved (age, gender, presence of hematuria, serum creatinine [mg/dL], proteinuria [g/24 h]). Renal biopsy findings were classified according to Haas single grade classification scheme and the Oxford Classification of IgAN. 600 cases of IgAN were identified, of which 568 (94.7 %) were on native kidneys. Male to female ratio was 1.24:1. Patients averaged 32.76 ± 15.12 years old (range 4–89, median 32). Proteinuria and hematuria were observed, respectively in 56.63 and 72.29 % of patients. The association of both these findings occurred in 37.95 % of the cases. Serum creatinine averaged 1.65 ± 0.67 mg/dL (median 1.5 mg/dL) at diagnosis. Segmental sclerosis and mesangial hypercellularity were the main glomerular findings (47.6 and 46.2 %) The commonest combination by Oxford Classification of IgAN, was M0 E0 S0 T0 (22.4 %). Chronic tubulo-interstitial lesions with an extension wider than 25 % of the renal cortex could be identified in 32.2 % of the cases. Tubular atrophy and interstitial fibrosis were more strongly associated with higher 24-h proteinuria and serum creatinine levels. Segmental sclerosis (S1) showed a stronger tendency of association with the presence of tubulo-interstitial lesions (T1 and T2) than other glomerular variables. To the best of our knowledge this is the largest series of IgAN in Brazil. It depicts the main biopsy findings and their possible clinical correlates. Our set of data is comparable to previous reports.

Context: The principles behind the process of creating new, spontaneous sequences out of previously ordered nondeclarative stimuli have been scarcely addressed and, for such reason, remain highly unknown. Objective: This paper has four interconnected goals: (1) introduce a new software-based neuropsychological test that can be used as a mean to assess key aspects of the way people order and reorder non-declarative stimuli, based upon cognitive dissonance principles; (2) introduce a mathematical approach to the latter in ordering/re-ordering of non-declarative stimuli; (3) assess whether the principles of cognitive dissonance in ordering/re-ordering hold for a cohort of young adults with upper socioeconomic level; (4) access the extent to which the same holds for children and adolescents and trace a curve of maturation of cognitive dissonance in ordering/re-ordering. Methods: Our multi-age and multi-language social Network Test has two stages, first subjects must order figures representing human faces in accordance with their preference; next, different pairs of figures are automatically provided and each subject is asked to fulfill the intermediate arrays that are assumed to interconnect the original pair. Our mathematical model is centered around the relation defined by increases in the distance separating these different pairs of figures in the initial order (distances 1, 5 and 11) and related increases in the mean number of intermediate arrays placed in the reordering phase; 105 subjects were tested. Results: The tendency to produce reorders that are consonant to the one produced in the initial phase increases with age (in other words: people feel that there are more intermediate arrays between any two individuals to which they attribute divergent affect than the contrary). This trend inspired us to propose a cognitive dissonance index in spontaneous ordering/reordering of non-declarative stimuli, which may formalize the operation of a previously unknown cognitive dimension of the human mind and may serve as an index of cognitive maturation. To the extent that further studies endorse these perspectives, the tests, formulas, and theoretical principals may support new diagnostic methods and explorations in cognitive science. www.sciedu.ca/jbgc