The design of reinforced concrete (RC) frames is made on a member-by-member basis. Similarly, in the literature, the reliability of RC beams and columns is often studied in isolation from the rest of the structure. Yet, in the construction of regular frames, symmetry and regularity are often exploited, resulting in the same design for each element type. This is despite of different load effects on different parts of the structure, which leads to significant variations in the failure probability of the elements. Hence, in this paper, we investigate the reliability of members and the distribution of load effects in regular RC frame buildings, considering intact and column loss cases, where symmetry is lost. Results show that the ratios of normal-to-bending loads change significantly along building height, and this has a significant impact on reliability of individual columns.