The emergence of Zika virus in the Americas has caused an increase of babies born with microcephaly or other neurological malformations. The differential diagnosis of Zika infection, particularly serological diagnosis, is an important but complex issue. In this study, we describe clinical manifestations of 94 suspected cases of congenital Zika from Bahia state, Brazil, and the results of serological tests performed on children and/or their mothers at an average of 71 days after birth. Anti‐Zika immunoglobulin M (IgM) antibodies were detected in 44.4% and in 7.1% of samples from mothers and children, respectively. Nearly all the IgM, and 92% of immunoglobulin G positive results were confirmed by neutralization test. Zika specific neutralizing antibodies were detected in as much as 90.4% of the cases. Moreover, dengue specific neutralizing antibodies were detected in 79.0% of Zika seropositive mothers. In conclusion, Zika IgM negative results should be considered with caution, due to a possible rapid loss of sensitivity after birth, while the NS1‐based Zika IgM enzyme‐linked immunosorbent assay test we have used has demonstrated to be highly specific. In a high percentage of cases, Zika specific neutralizing antibodies were detected, which are indicative of a past Zika infection, probably occurred during pregnancy in this population.
Embora a Doença de Parkinson (DP) tenha sido tradicionalmente considerada uma desordem do sistema motor por um longo tempo, atualmente, é reconhecida como uma condição complexa com diversas características clínicas que incluem desordens neuropsiquiátricas e outras manifestações não motoras, além de sua sintomatologia motora. Atualmente, a Doença de Parkinson deve ser entendida como uma desordem sistêmica pelos vastos sintomas motores e não motores que estão associados a essa condição. Os sintomas não motores na DP são variados e podem preceder o diagnóstico da DP em até décadas e influem diretamente na qualidade de vida do indivíduo. Daí a importância de os sintomas não motores serem buscados de forma ativa pelo profissional que acompanha o paciente com DP. A gestão desses sintomas não motores deve ser individualizada, levando sempre em consideração as comorbidades e a respectiva farmacoterapia em uso.
A nova síndrome respiratória aguda grave causada pelo novo coronavírus (SARS-CoV-2) surgiu em Wuhan, China, e rapidamente se espalhou pelo mundo. Embora a apresentação clínica predominante seja a doença respiratória, as manifestações neurológicas são cada vez mais reconhecidas. Neste relato, demonstramos um caso de encefalite hemisférica como manifestação neurológica do SARS-CoV-2 em uma mulher de 74 anos internada no Hospital Santa Izabel (HSI) entre maio e julho de 2020.
Context: The novel severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) emerged in Wuhan, China and rapidly spread worldwide. Although the predominant clinical presentation is with respiratory disease, neurological manifestations are being recognised increasingly. Case report: In this report, we demonstrate a case of hemispheric brain in volvement as a neurological manifestation of Sars-cov-2 in a 74-year-old patient admitted to Hospital Santa Izabel (HSI) between May and July 2020. Conclusion: In COVID-19, although the predominant clinical presentation is with respiratory disease, neurological complications have been reported. Severe neurological complications are either because of direct viral invasion, immunological reaction, or hypoxic metabolic changes. The patients with encephalitis are usually severely or critically ill.
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