We present a new approach to structure learning in the field of Bayesian networks: We tackle the problem of the search for the best Bayesian network structure, given a database of cases, using the genetic algorithm philosophy for searching among alternative structures. We start by assuming an ordering between the nodes of the network structures. This assumption is necessary to guarantee that the networks that are created by the genetic algorithms are legal Bayesian network structures. Next, we release the ordering assumption by using a "repair operator" which converts illegal structures into legal ones. We present empirical results and analyze them statistically. The best results are obtained with an elitist genetic algorithm that contains a local optimizer.

In this paper we present a new methodology for inducing Bayesian network structures from a database of cases. The methodology is based on searching for the best ordering of the system variables by means of genetic algorithms. Since this problem of nding an optimal ordering of variables resembles the traveling salesman problem, we use genetic operators that were developed for the latter problem. The quality of a variable ordering is evaluated with the algorithm K2. We present empirical results that were obtained with a simulation of the ALARM network.

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Abstract-Simplified lattice models have played an important role in protein structure prediction and protein folding problems. These models can be useful for an initial approximation of the protein structure, and for the investigation of the dynamics that govern the protein folding process. Estimation of distribution algorithms (EDAs) are efficient evolutionary algorithms that can learn and exploit the search space regularities in the form of probabilistic dependencies. This paper introduces the application of different variants of EDAs to the solution of the protein structure prediction problem in simplified models, and proposes their use as a simulation tool for the analysis of the protein folding process. We develop new ideas for the application of EDAs to the bidimensional and tridimensional (2-d and 3-d) simplified protein folding problems. This paper analyzes the rationale behind the application of EDAs to these problems, and elucidates the relationship between our proposal and other population-based approaches proposed for the protein folding problem. We argue that EDAs are an efficient alternative for many instances of the protein structure prediction problem and are indeed appropriate for a theoretical analysis of search procedures in lattice models. All the algorithms introduced are tested on a set of difficult 2-d and 3-d instances from lattice models. Some of the results obtained with EDAs are superior to the ones obtained with other well-known population-based optimization algorithms.Index Terms-Estimation of distribution algorithm (EDAs), hydrophobic-polar (HP) model, protein folding, protein structure prediction.

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