The regional innovation system (RIS) is a popular way of explaining a region's development and competitiveness based on innovation activities and processes. In this paper, bibliometric techniques are used to analyze all RIS studies indexed in the Web of Science Core Collection (WoS CC) database as of December 2017. The goal of the analysis is to identify the main trends in RIS research. The evolution of the total number of publications and citations per year indicates that this research field has garnered considerable attention from the scientific community, public administrations, and international organizations. Analysis of the most common keywords and their co-occurrence sheds light on the conceptual framework of RIS research, where knowledge, innovation, clusters, policy, networks, systems, R&D, firms, and industry are key concepts. The 17 most influential RIS articles indexed in WoS CC are identified according to the total number of citations and the ratio of number of citations per year. Reviewing these 17 articles reveals 3 groups of underlying research trends: (1) research on innovation systems, which was mainly conducted in the 1990s, (2) research on knowledge management since the beginning of the 2000s, and (3) research on entrepreneurial ecosystems in recent years. Finally, analysis of citations to these 17 most influential RIS articles reveals strong interconnections according to the number of times they are cited together.

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National systems of innovation (NSI) have attracted substantial interest from public administrations, the scientific community and international organizations. Innovation is a key factor for countries to be competitive in the today’s global economy. Entrepreneurship is an innovation source that has gained importance in NSI research over the last few decades. This focus on entrepreneurship in the context of NSI has led scholars to propose novel concepts such as entrepreneurial ecosystems and the national system of entrepreneurship (NSE). This paper uses bibliometric methods and the Web of Science Core Collection (WoS CC) database to explore how entrepreneurship fits into NSI research and to study the increasing importance of entrepreneurship within this research field. The NSI conceptual framework is developed according to the most common keywords, and the most influential NSI studies are identified using the total number of citations and the ratio number of citations per year. Two sets of studies are analyzed: (1) older documents on traditional topics such as the origins and evolution of NSIs, the capacity of countries to innovate, and the relationships of institutions, different organizational forms, networking, production and competence building with innovation and (2) newer entrepreneurship research documents. Based on analysis of the most common keywords, the most influential studies and multiple entrepreneurship approaches, we propose a Sextuple Helix model as an analytical framework that brings together innovation and entrepreneurship.

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This article uses the data indexed in the Web of Science Core Collection and Scopus databases up to and including the year 2020 to map leading regions and trending topics in academic innovation policy research.The country analysis highlights four leading regions in this research field: Western Europe (led by the UK, the Netherlands, Germany, and Spain), North America (led by the United States), Scandinavia (led by Sweden and Denmark), and Asia-Pacific (led by China and Australia). The most common keywords are used to develop a conceptual framework. Applying the Tree of Science approach, we classify the most influential studies into three categories: foundational studies (the roots), structural studies (the trunk), and recent studies (the leaves). This approach shows that trending topics are built around five main pillars: innovation systems, policy tools, knowledge management, sustainability, and entrepreneurship. Finally, based on analysis of the most common keywords and the most influential studies, we propose a Sextuple Helix model. This model consists of the Quintuple Helix (government, university, industry, knowledge society, and sustainability) with the added dimension of entrepreneurship. This model offers an analytical framework with massive potential for academic research on innovation policy in the current economic context.