Aculeacin A acylase from Actinoplanes utahensis produced by Streptomyces lividans revealed acylase activities that are able to hydrolyze penicillin V and several natural aliphatic penicillins. Penicillin K was the best substrate, showing a catalytic efficiency of 34.79 mM ؊1 s ؊1 . Furthermore, aculeacin A acylase was highly thermostable, with a midpoint transition temperature of 81.5°C.
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