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Purpose: To carry out a meta-analysis of potential genetic association studies in order to determine whether the FGF10 polymorphism rs339501 is related to myopia. Method: All the eligible case control studies examing the association of FGF10 polymorphisms and myopia published up to 20 January 2022 were retrieved from MEDLINE, Embase, the Cochrane library, Web of Science, the China National Knowledge Infrastructure (CNKI) and the VIP database of Chinese periodicals without language restriction. Depending on the heterogeneity among studies, a fixed-effect model or a random-effect model was chosen to compute the 95% confidence intervals (95%CIs) and odds ratios (ORs) for single nucleotide polymorphism (SNP). Publication bias were analyzed by examining the symmetry of the funnel plots and further confirmed by Begg’s and Egger’s tests. Stability of the analyses was checked by the sensitivity analysis.Results：6 studies were finally included in our analysis. The subgroup analyses focusing on Chinese population found some significant results, which mainly fell on the recessive model and homozygote model(p<0.05), especially for the high myopia, of whom the pooled results in allelic model and dominant model(p＜0.05) were also significant. Additionally, the allelic model(p＜0.05) for the correlation between SNP rs339501 and myopia was also significant in Chinese population. Unfortunately, our analysis for the overall population did not reach a statistically significant result.Conclusion: G allele of SNP rs339501 would increase the risk of myopia for Chinese population. Large-scale researches are still needed to corroborate the associations.

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