Epileptic seizure prediction is one of the most used therapeutic adjuvant strategies for drug-resistant epilepsy. Conventional approaches commonly collect training and testing samples from the same patient due to inter-individual variability. However, the challenging problem of domain shift between various subjects remains unsolved, resulting in a low conversion rate to the clinic. In this work, a domain adaptation (DA)-based model is proposed to circumvent this issue. The short-time Fourier transform (STFT) is employed to extract the time-frequency features from raw EEG data, and an autoencoder is developed to map these features into high-dimensional space. By minimizing the inter-domain distance in the embedding space, this model learns the domain-invariant information, such that the generalization ability is improved by distribution alignment. Besides, to increase the feasibility of its application, this work mimics the data distribution under the clinical sampling situation and tests the model under this condition, which is the first study that adopts the assessment strategy. Experimental results on both intracranial and scalp EEG databases demonstrate that this method can minimize the domain gap effectively compared with previous approaches.

Epileptic seizure prediction is one of the most used therapeutic adjuvant strategies for drug-resistant epilepsy. Conventional methods usually adopt handcrafted features and manual parameter setting. The over-reliance on the expertise of specialists may lead to weak exploitation of features and low popularization of clinical application. This paper proposes a novel parameterless patient-specific method based on Fourier Neural Network (FNN), where the Fourier transform and backpropagation learning are synthesized to make the predictor more efficient and practical. The employment of FNN is the first attempt in the field of seizure prediction due to its automatic extraction of immanent spectra in epileptic signals. Despite the self-adaptive superiority of FNN, we introduce Convolutional Neural Network (CNN) to further improve its search capability in high-dimensional feature spaces. The study also develops a multi-layer module to estimate spectral power ratios of raw recordings, which optimizes the prediction by enhancing feature diversity. Based on these modules, this paper proposes a two-channel deep neural network: Fourier Ratio Convolutional Neural Network (FRCNN). To demonstrate the reliability of the model, we explain the mathematical meaning of hidden-layer neurons in FRCNN theoretically. This approach is evaluated on both intracranial and scalp EEG datasets. It shows that the predictor achieved a sensitivity of 91.2% and a false prediction rate (FPR) of 0.06[Formula: see text]h[Formula: see text] across intracranial subjects and a sensitivity of 85.4% and an FPR of 0.14[Formula: see text]h[Formula: see text] over scalp subjects. The results indicate that FRCNN enables the convenience of epilepsy treatments while preserving a high degree of precision. In the end, a detailed comparison with the previous methods demonstrates that FRCNN has achieved higher performance and generalization ability.

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