Objective: This study aimed to evaluate the analgesic efficacy and opioid-sparing effect of duloxetine in adults having arthroscopic rotator cuff repair, as well as its clinical safety.Methods: In this randomized trial, 120 adults having arthroscopic rotator repair were randomized to receive perioperative oral duloxetine or placebo. The primary outcome was patient selfreported pain score (Visual Analog Scale: 0 to 10) at rest and opioid consumption within postoperative 2 days. Other outcomes included adverse effects, changes of thromboelastogram, and hemoglobin indicators before and after the operation.Results: A total of 120 patients were included in the intention-to-treat analysis, of which 60 received duloxetine and 60 received placebo. Groups were similar on the demographic, baseline, and intraoperative variables.

BackgroundThe radiological indicators can help doctors determine whether to make the tibial tubercle transfer. But that which indicator is better is still in question.Methods117 knees in 103 patients who had gone through patellar surgery and 60 knees in 58 patients who had no history of patellar dislocation from 2014 to 2019 were analyzed. Significant differences of tibial tubercle–trochlear groove (TT-TG) on CT and tibial tubercle–posterior cruciate ligament (TT-PCL) on MRI between the case group and the control group were estimated by an unpaired t test. Significant differences between TT-TG on CT and TT-TG on MRI were estimated by a paired t test. The correlation between TT-PCL on MRI and tibial width was estimated by Pearson test. Receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were measured to assess the diagnostic accuracy of TT-TG and TT-PCL on MRI. ResultsThe intraclass correlation coefficient (ICC) for inter-method of TT-TG evaluated by two raters was were 0.566. When comparing TT-TG on CT with that on MRI, the mean difference was 2.5mm (p<0.001). The mean TT-TG difference on CT between the case group and the control group was 5.3 mm, which was significantly bigger than the mean TT-PCL difference on MRI of 1.2mm(p<0.001). AUC of TT-TG on CT and TT-PCL were 0.838 and 0.580 (P<0.001). TT-PCL correlated with tibial width (r=0.450, P<0.001). ConclusionA statistically significance and a fair ICC proved that TT-TG could not be used interchangeably. The bigger mean difference between the case group and the control group and better AUC proved that TT-TG on CT might be an indicator more suitable for measuring the lateralization of the tibial tubercle. And TT-TG should be considered as an individual parameter because of the significant correlation with tibial width.