Since 2002, building information modelling (BIM) has flourished expeditiously and has been adopted broadly in the field of built environment. In step with this explosive implementation and adoption, scores of articles have been published on BIM. Given this flood of documents over the last decade, the objective of this study to use a bibliometrics approach to help discover and benchmark the most valuable and highly cited publications in this burgeoning area. Not only do these techniques facilitate the identification of research clusters and topics in BIM community, but the approaches help highlight how research topics evolve over time, greatly contributing to understanding the underlying structure of the BIM knowledge base, domain, and evolution. Based on the knowledge base, knowledge domain and evolution of BIM knowledge, a BIM knowledge map is proposed. Although the depth and scope of this analysis

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Interactions between factor Va and membrane phosphatidylserine (PS) regulate activity of the prothrombinase complex. Two solvent-exposed hydrophobic residues located in the C2 domain, Trp(2063) and Trp(2064), have been proposed to contribute to factor Va membrane interactions by insertion into the hydrophobic membrane bilayer. However, the prothrombinase activity of rHFVa W(2063, 2064)A was found to be significantly impaired only at low concentrations of PS (5 mol %). In this study, we find that 10-fold higher concentrations of mutant factor Va are required for half-maximal prothrombinase activity on membranes containing 25% PS. The ability of the mutant factor Va to interact with factor Xa on a membrane was also impaired since 4-fold higher concentrations of factor Xa were required for half-maximal prothrombinase activity. The interaction of factor Va with 25% PS membranes was also characterized using fluorescence energy transfer and surface plasmon resonance. We found that the affinity of mutant factor Va for membranes containing 25% PS was reduced at least 400-fold with a K(d) > 10(-7) M. The binding of mutant factor Va to 25% PS membranes was markedly enhanced in the presence of factor Xa, indicating stabilization of the factor Va-factor Xa-membrane complex. Our findings indicate that Trp(2063) and Trp(2064) play a critical role in the high-affinity binding of factor Va to PS membranes. It remains to be determined whether occupancy of this PS binding site in factor Va is also required for high-affinity binding to factor Xa.

Prefabrication housing production (PHP) is widely promoted due to its potential benefits, such as reduced construction time and improved quality. However, PHP also faces many uncertainties and constraints due to the highly fragmented process of managing design, construction, and supply chain. Lean Construction principles and information technologies, e.g. Radio Frequency Identification (RFID) and Building Information Modeling (BIM), have proven to be effective to help reduce the uncertainties and remove the constraints in PHP. However, the availability of appropriate training or pedagogical approaches to transfer and share the lean knowledge and information techniques has impeded their adoption. To address the issue, this study develops a hands-on learning tool, an advanced simulation game called RBL-PHP (i.e. RFID/BIM/Lean-Prefabrication Housing Production), which simulates the process of PHP from manufacturing, logistics to the on-site assembly by integrating an RFID-enabled BIM platform with Lean Construction to training students and practitioners. Four workshops are conducted at The Hong Kong Polytechnic University, Hong Kong, China, to assess the participants' learning experience by using ex-ante and ex-post surveys. In each workshop, the performance of PHP is tested separately in a traditional round and a RFID/BIM/Lean (RBL)-enabled round on indicators including the percentage of plan complete (PPC), This material may be downloaded for personal use only. Any other use requires prior permission of the American Society of Civil Engineers.