Samarium diiodide promotes intramolecular cascade radical cyclizations of cyanamide radical precursors conveniently to afford polycyclic N-heterocycles in moderate to good yields.
Employing a CuI/2,2'-biimidazole catalyst system, the intramolecular C-N coupling reactions of various substituted aryl guanidines could be successfully carried out under mild conditions. A variety of 1-cyanobenzimidazoles were synthesized in good to excellent yields.
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