The development of robust electrocatalysts for electrocatalytic hydrogenation (ECH) of guaiacol and related lignin model monomers is necessary for the stabilization or upgrading of bio‐oil. Additionally, the efficiency of biomass conversion to bio‐oil products remains below the minimum requirements for its implementation at scale. Herein, a PtNiB/CMK‐3 catalyst with pronounced ECH performance in the conversion of guaiacol and related model lignin monomers to bio‐oil under optimally mild conditions, through a modulation strategy that modified the electronic structure of PtNi via boron alloying, is prepared. Notably, the optimized PtNiB/CMK‐3 exhibited an inspiring high faradaic efficiency of 86.2%, which is significantly higher (13.7 times) than that of the PtNi/CMK‐3 without B‐doping (6.3%). Experimental results and theoretical calculations showed that the B‐doping optimized the PtNiB alloy surface electron structure, simultaneously promoting substrate and intermediate adsorption and the ECH process. In addition, the uniform dispersion of PtNiB nanoparticles embedded within the mesoporous channels of CMK‐3 ensures an enhanced utilization efficiency, leading to improvements in stability and bio‐oil product generation. The lab‐scale ECH experiment of guaiacol also certified the scale‐up potential. This work opens a promising avenue to the rational design of advanced and highly efficient electrocatalysts for biomass upgrading.

An I2-mediated metal-free oxidative C-N bond formation methodology has been established for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol requires no isolation of the less stable intermediates hydrazones and provides a facile access to a variety of di-, tri-, and tetrasubstituted (aryl, alkyl, and/or vinyl) pyrazoles from readily available α,β-unsaturated aldehydes/ketones and hydrazine salts.

2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.

In this study, thermoresponsive and mussel-inspired polypeptides were synthesized using ring-opening polymerization of α-amino acid derivatives of N-carboxyanhydride (NCA). The tissue adhesive properties of these polypeptides were evaluated using in vitro adhesive strength tests on porcine skin and bone. The results indicated that the species of the functional polypeptide side groups and the adhesive temperature have a significant influence on the adhesion strength. The maximum of the lap-shear adhesion strength on porcine skin was 101.2 kPa, and the maximum of tensile adhesion strength on bone was 603 kPa. The in vivo antibleeding activity and tissue adhesive ability were also evaluated using a rat model. These polypeptides exhibited superior hemostatic properties and healing effects in the skin incision and osteotomy gap, and the skin incision healing and osteotomy gap remodeling were completed in all rats after 2–9 weeks. These polypeptides are expected to be good candidates for surgical tissue adhesives, tissue engineering materials, and antibleeding materials, etc.

The one-electron reduction (OER) can profoundly affect the structure and reactivity of organic compounds. OER induced radical decarboxylative functionalizations of redox-active esters have gained wide concerns in this century. In this 1. Introduction 2. Mechanism outline 3. OER of Redox-Active Esters to form C(sp 3)-C(sp 3) bonds 4. OER of Redox-Active Esters to form C(sp 3)-C(sp 2) bonds 5. OER of Redox-Active Esters to form C(sp 3)-C(sp) bonds 6. OER of Redox-Active Esters to form C-X bonds 7. Conclusion and Perspective [a