No abstract

An unstable rhodium alkyl has been character-spectroscopy Thus (RR) -1,2-bis-(o-methoxyphenylised by n m r spectroscopy a t low temperatures under the phenylphosphino)ethane2 rhodium complexes of cx-benzconditions of homogeneous hydrogenation amidocinnamic acid (la) and its methyl ester (lb) exist as two diastereomers in ratio 10: 1 at room temperature These are co-ordinated to rhodium through olefinic and amide groups3 and differ in configuration of bound olefin At room temperature they disappear concomitantly on exposure to hydrogen ---IN previous papers we have described the formation of rhodium complexes derived from dehydroamino acids and their charactensation by phosphorus and carbon n m r 7 Rhodium complexes with mutually trans alkyl and phosphine ligands are rare W Keim,

The structure of 2,2'-bithiophene, C8H652, has been redetermined at low temperature (173 K) with a good degree of accuracy. The molecules are planar and although the transoid form predominates, there is some disorder.

A range of substituted oligothiophenes has been prepared and characterised. Crystal structures were determined for three substituted terthiophenes. Both in solution and in the solid state, syn-conformers were found to be populated to a greater extent than expected.

The complex cis,trans,cis-[PtCl(2)(OAc)(2)NH(3)(c-C(6)H(11)NH(2))] (JM-216) is currently undergoing clinical evaluation as an antitumor agent. In support of characterization and analysis of this complex a study of its isomers and other complexes [PtCl(m)()(OAc)((4)(-)(m)()())NH(3)(c-C(6)H(11)NH(2))] (m = 0-4) has been undertaken. The complexes have been obtained by a variety of synthetic routes which now extend the scope for the preparation of platinum(IV) antitumor complexes. As platinum(IV) complexes are very stable to substitution in the absence of catalysis, use has been made of both light and base catalysis to promote substitution. Oxidative addition to platinum(II) using hypervalent iodine reagents has also been used. The stereochemistry of the complexes has been confirmed by spectroscopic studies, primarily NMR including natural abundance (15)N NMR spectroscopy.