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019 AbstractPurpose: The purpose of this report is to present a case of optic neuropathy as a manifestation of secondary syphilis in an HIV-negative patient. Methods:We describe a case of gradual loss of visual acuity in the left eye (LE) in a 53-year-old healthy woman. Results:The patient presented with visual acuity of 20/20 in the right eye and hand movements in the LE. Fundoscopy revealed swollen optic disc in the LE. Fluorescein angiography showed leakage of dye from the optic disc. Optical coherence tomography (OCT) confirmed the oedema in the left optic disc. Serologic testing was positive for venereal disease research laboratory (VDRL) and fluorescent treponemal antibody absorption (FTA-ABS), and negative for HIV antibodies. Conclusions:Ophthalmologic findings, including disc oedema, may be the presenting features of syphilis, therefore ophthalmologists have the opportunity to play a key role in the diagnosis and management of this disease, important for a good visual outcome.pressure was 12mmhg in both eyes. Fundoscopy showed a swollen optic disc in the LE, with no abnormalities detected in the RE. A left relative afferent pupillary defect was present ( Figure 1 and Figure 2).Fluorescein angiography showed leakage of dye from the optic disc. Optical coherence tomography (OCT) confirmed the oedema in the left optic disc.Serologic testing was positive for VDRL (1:128) and FTA-ABS, and negative for HIV antibodies. No abnormalities were detected during magnetic resonance imaging of the cranium and orbits.

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