Background: From the perspective of the Roy Adaptation Model, leprosy is seen as a focal stimulus with severe psychological repercussions that force persons to modify their behavior in order to avoid being rejected by the social stigma the disease creates, thus inducing in them an ineffective adaptive response of the self-concept mode. The aim of the present work was to describe the effect of the directed imagination technique at the adaptation level of the self-concept mode in persons with leprosy in Colima, Mexico during 2012.