Background: Chemotherapy with multiple drugs has been a crucial step in the treatment of Multiple Myeloma producing a high deep response rate and improving progression-free survival and overall survival. The efficacy of bortezomib in the induction of remission has been demonstrated in different studies. Cytotoxic drugs such as Doxorubicin, Cyclophosphamide or Thalidomide have been combined with Bortezomib / Dexamethasone. There are few randomized studies comparing remission with Bortezomib / Dexamethasone with Cyclophosphamide, Doxorubicin or Thalidomide inductions treatments.
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