Stress is a state of physical and psychological strain which imposes demand for adjustment upon the individual. It is common features in all our lives. Psychosocial stress is the result of cognitive appraisal of what is at stake and what can be done about it. In the study, “A comparative study on psychosocial stress among male and female adults (40-60years) of district Mandi. A quantitative research approach and comparative design was used to assess the level of psychosocial stress among male and female adults. Total sample of study were 100 male and female adults. A convenience sampling technique was used to select the sample. A self-structured psychological and psychosocial stress scale were prepared to assess the level of psychosocial stress among male and female adults. The result of the study were significance association between the psychosocial stress with educational and occupational status in males lies between moderate level which influence the level of psychosocial stress i.e. 44(88%) in males and 24(48%) in females. The study concludes that male and female adults have moderate psychosocial stress.