Objective To investigate the effect of inflammation on the conducting system of the heart in patients diagnosed with brucellosis. Methods A total of 42 patients diagnosed with brucellosis and 39 age and sex-matched healthy children were enrolled into the study. Pre- and post-treatment electrocardiographic parameters in brucellosis and control group were recorded from an electrocardiogram for each patient. Results The results indicated that the parameters including Pmax, Pdis, QTmax, QTdis, QTcdis, Tp-edis interval and Tp-emax/QTmax and Tp-emax/QTcmax ratios, which are known to be key indicators for the prediction of severe atrial or ventricular arrhythmia and sudden cardiac death and also important parameters used as the indicators for the non-invasive evaluation of the transmural heterogeneity were significantly longer in the study group compared with the control group (p < 0.05). Conclusion In this study, it was determined that the brucella disease had more cardiac involvement than thought, and this was more in the subclinical form of cardiac involvement.

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DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a rare type of delayed drug hypersensitivity reaction characterised by fever, skin rash, lymphadenopathy, and visceral involvement, which can be life threatening and is a childhood event. An eight-year-old boy was admitted with complaints of extensive rash and fever three weeks after the onset of treatment with carbamazepine for a diagnosis of epilepsy. Fever, as well as patches and plaques with indeterminate limits that tended to merge and were non-blanchable on a widespread erythematous layer, were revealed in physical examination. Extensive cervical, submandibular, and inguinal lymphadenopathy was observed. We present ours as the second case of myocarditis secondary to DRESS syndrome after carbamazepine use in the literature.

Background: Congenital heart disease (CHD) is commonly seen in patients with Down syndrome (DS) and is closely associated with morbidity and mortality. Maternal age is an established risk factor for DS. Objectives: The aim of the present study is to analyze the incidence of CHD in Down syndrome and the effect of maternal age on this incidence and the type of CHD. Materials and Methods: Six hundred and thirty-one patients with DS who were admitted to pediatric cardiology department, between December 2014 and December 2018, were retrospectively analyzed. The detected CHDs were evaluated in association with maternal age. Results: Four hundred forty-five (70.5%) cases had one or more congenital heart defect. Two hundred and seven patients (32.8%) had isolated simple defect while the remaining had complex or associated multiple CHDs (n:238, 37.7%). Considering all patients, secundum ASD (42.1%) was the Original Research Article