Objective: Bibliographically analyze the challenges, importance and difficulties of adherence to treatment in individuals with celiac disease. Bibliographic review: Celiac disease (CD) is an autoimmune disease due to intolerance to gluten, which makes it difficult for the body to absorb nutrients and water. CD has a prevalence of up to 1% of the world's population, of which approximately 300,000 Brazilians are carriers. The pathophysiology of CD occurs by an inflammatory activation that occurs mainly by immunological processes mediated by T cells, damaging the microvilli and leaving the intestine with a smooth appearance. Due to the inflammatory process, the classic picture of malabsorption generates symptoms that include diarrhea, steatorrhea and lack of appetite, as well as extra intestinal manifestations that include dermatitis, malnutrition, pubertal delay and others. Currently, it is understood that there are not many treatment options for CD, since the gluten-free diet is the only one that is effective for these patients. Therefore, adherence to such therapy is not so simple, since there are a number of social and economic difficulties that hinder this process. Final considerations: Although CD has a simple therapeutic option, it involves several intercurrences which impair adherence to treatment and can cause consequences for celiac patients. That said, promoting access to information about CD is important not only for celiac patients, but also for the general population in order to facilitate better and simplified access to gluten-free products.
Introdução: A pancreatite aguda é caracterizada por uma inflamação de variadas etiologias sendo as principais colelitíase e etilismo. A prevalência da inflamação, no Brasil, encontra-se por volta 15,9/100.000. Diante dessa situação o objetivo desse estudo é descrever a fisiopatologia, manifestações clínicas, diagnóstico laboratorial, possíveis complicações sistêmicas e locais, bem como o tratamento da pancreatite aguda. Metodologia: Utilizou-se artigos com texto completo disponíveis nas bases de dados Google Acadêmico, Biblioteca Virtual em Saúde e PubMed. Resultados: 19 artigos foram identificados no período de estudo, todos com publicação de 2012 a 2022. Contudo, notou-se que o consumo abusivo de álcool apresenta implicações importantes na saúde pública em nível nacional e mundial, sendo essa etiologia causadora de 30% das pancreatites agudas, atingindo, em sua maioria, homens jovens com histórico de etilismo abusivo. Dessa forma, uma estimativa em nível global evidenciou que cerca de 237 milhões de homens e 46 milhões de mulheres são afetados com enfermidades relacionados ao uso abusivo de álcool. Conclusão: O diagnóstico da Pancreatite aguda deve ser clínico-laboratorial, sendo que o manejo inicial do paciente visa tratamento dos sintomas e voltado ao suporte, visto que ainda não há relatos conclusivos voltados a cessar a progressão da doença.
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