Human peripheral lymphocytes, identified as T o r B cells with a fluorescent anti-globulin serum, were studied in two varieties of rosette formation:(1) with sheep red corpuscles, a phenomenon shown by a large proportion of human lymphocytes and totally different from that observed in the mouse; and (2) with human red cells sensitized with incomplete anti-Rh. Lymphocytes forming sheep cell rosettes were never fluorescent; i.e. they were T cells. 73 % of lymphocytes forming sensitized-cell rosettes were fluorescent B cells. Horse anti-human lymphocyte serum inhibits the first but not the second variety of rosette formation.
Summary
Bantu blood samples of group A, when tested for agglutination with Dolichos anti‐A1 reagent, do not show the sharp differentiation into Al and A2 that is found in specimens from Caucasians.
They may he classified as A1, reacting strongly with Dolichos reagent; an intermediate group reacting weakly; and two groups that do not react — A2 and a weak form named Abantu. None of these subgroups is rare.
Intermediates, though they have mean A scores lying between A1 and A2, have higher mean agglutination titres against Ulex anti‐H than do A2 samples. The mean H level of intermediates, in fact, does not differ significantly from that of O cells. Bantu bloods of all ABO groups have far higher mean H levels against Ulex reagent than do Caucasian samples of corresponding group.
The A bantu group shows an A3 pattern of agglutination with potent anti‐A reagents and with O serum, but there is no A substance in the secretor salivas examined and anti‐A1. active at room temperature, is regularly present in the serum.
Résumé
Des échantillons de sang de Bantous de groupe A lorsqu'ils sont testés avec un réactif anti‐A1 provenant de Dolichos ne démontrent pas la différenciation nette entre des échantillons A1 et A2 ainsi qu'on le trouve chez des échantillons de Caucasiens. Ces échantillons de Bantous doivent être classifiés en A1 réagissant très fortement avec le réactif Dolichos; en une forme intermédiaire réagissant faiblement; et en deux groupes qui ne réagissent pas dont l'un est le type A2 et l'autre une forme faible appelée Abantou. Aucun de ces sous‐groupes est rare.
Les formes intermédiaires qui se situent entre la forme A1 et A2, ont un titre moyen d'agglutination plus élevé contre l'anti‐II Ulex que les échantillons A2. Le taux moyen de substance H des formes intermédiaires, en fait, ne diffère pas de manière significative de celui des érythrocytes O. On observe que les échantillons de sang de Bantous des groupes A, B, O ont un taux moyen de substance H mis en évidence au moyen du réactif Ulex plus élevé que les échantillons des Caucasiens provenant de groupes correspondants. Le groupe Abantou se comporte au point de vue agglutination comme des érythrocytes A3 avec des réactifs anti‐A puissants et avec les sérums O, mais il n'y a pas de substance A dans la salive des secréteurs examinés et de l'anti‐A1 actif à la température de chambre se trouve régulièrement dans le sérum de ces sujets.
Zusammenfassung
Bantu‐Blutproben der Gruppe A zeigen bei Prüfung mit Dolichos Anti‐A1‐Reagentien nicht die scharfe Unterteilung in A1 und A2, wie dies bei Kaukasiern üblich ist.
Sie lassen sich vielmehr wie folgt gruppieren: A1 mit kräftiger Reaktion mit Dolichos‐Extrakt; A‐intermediär mit schwacher Reaktion; zwei Gruppen, welche nicht reagieren: nämlich A2 und eine schwache A‐Eigenschaft, die als Abantu bezeichnet wird. Keine dieser Untergruppen ist selten.
Intermediärformen mit A‐Scores zwischen A1 und A2 zeigen im Ansatz mit Ulex Anti‐H höhere Durchschnittstiter als A2‐Zellen. Der mittlere H‐Gehalt dieser Intermediärformen weich...
Immune responses in 24 children with acute measles (AM) were compared with those in 20 children who had chronic pulmonary complications (CPMC) following measles. The immuno-suppressive effects of acute measles were extensive: total white cells were reduced and this reduction was accounted for entirely by lymphopenia which was equally expressed among the major lymphocyte sub-populations studied; the function of ‘T’ cells, assessed by radio-isotope incorporation into phytohaemagglutin (PHA) transformed lymphocytes and delayed skin hypersensitivity (DHR) to dinitrochlorobenzene (DNCB), was depressed. Serum IgA was reduced in AM patients. In contrast there was a relative sparing of the measured indices of immunity in patients with chronic post-measles chest disease, with the major defect being an impaired DHR to DNCB. There were minor alterations of complement components in both groups of patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.