SUMMARYThe study is based on a prospective survey of 200 necropsies, to determine the prevalence of colonic polyps and diverticula in Hong Kong. Adenomatous polyps were found in 34% of men and 19% of women. The corresponding figures for hyperplastic polyps were 22% and 15%. When compared with European countries having similar rates for colorectal cancer, the polyp pattern by type, prevalence, and distribution is very similar. For diverticula the prevalence rate in this study was only 5%; most of these were situated in the caecum. This is at marked variance to the European pattern.Adenomatous polyps have been established as the usual precursor of carcinomas of the large intestine. The incidence rates for colorectal carcinoma and the distribution pattern within the large intestine have been well documented for many countries, including Hong Kong,' 2 a population at intermediate risk.More recently, detailed information on the prevalence and distribution of adenomatous polyps has emerged from a number of prospective autopsy studies,31 but this information is still not available on a world wide basis. Methods NECROPSIESColons from 200 necropsies were collected at the Department of Pathology, Queen Mary Hospital, Hong Kong. This government hospital serves a population predominantly from lower socioeconomic groups. All cases were Chinese subjects. As far as possible the colons were collected consecutively from all patients over 10 years of age but excluding any with previous colonic surgery. A few intervening cases were not available for examination for a variety of reasons.The colons were collected by complete removal down to the pectinate line. They were opened, flushed with normal saline from a large tank, pinned out flat on polystyrene boards and fixed in 10% formalin for a minimum of 48 hours. Later, after

The term "nasal glioma" is a confusing misnomer as it implies a neoplastic condition with malignant potential, which it is not. Nasal glioma is a rare development abnormality and should be differentiated from glioma, which is a malignant tumor of the brain, and from a primary encephalocele, which is herniation of the cranial contents through a bone defect in the skull, through which it retains an intact connection with the central nervous system. Two cases of nasal glioma, one with and one without intracranial connections, are described and the literature is reviewed.

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Summary A 28‐year‐old patient with the Séry syndrome was treated with Cyclosporin A (CSA). After transient biochemical evidence of hepatic and renal toxicity his condition progressively improved as evidenced by diminished pruritus, partial resolution of erythroderma and reduction of circulating abnormal T‐cells, Eight months after treatment, sudden clinical deterioration heralded development of an aggressive T‐cell immunoblastic sarcoma with a leukaemic blood picture. Remission was induced by standard quadruple chemotherapy with reversion to Sézary syndrome, from which the patient eventually died. Recent reports suggest a high incidence of malignant lymphomas in transplant patients receiving CSA: some of these tumours are of B‐cell origin but others have not been fully documented. In this case the abrupt and early change in the course of the disease following therapy with CSA raises the possibility that the drug accelerated or altered the natural history. The need for precise immunological characterisation of lymphomas arising in patients receiving CSA is emphasized.

The pathology findings in two cases of multicentric reticulohistiocytosis are presented. Light microscopic and histochemical investigations were undertaken but emphasis is placed on the ultrastractural and tissue culture observations on these two cases. A range of immunological investigations performed on one of these patients is also reported.