No abstract

W e report a prospective double-blind randolnised cross over t r i a l designed t o compare the effect of a hypoallergenic formula NAN-HA with a standard cows' milk protein (whey dominant) formula NAN on 67 infants (45 M, 22 F ) aged 6 weeks t o 6 months. Records of sleep, crying, diarrhoea, c o l i c , regurgitation, skin rashes and coughs and wheezing were recorded for 2 three-week periods (one on each formula) following an i n i t i a l one week run-in period. Night sleep (between 8pm and 8am) was confirmed t o be less i n i t i a l l y in the "sleep disturbed" infants cornpared t o controls (p < 0.01). Sleep improved in the infants whether allocated HA or NAN f i r s t and improved throughout the 6 weeks of the t r i a l t o be no different from control infants a t the end.There was no significant difference between the two groups with respect t o any of the symptoms studied except that loose stools/diarrhoea were significantly increased ( p < 0.01) on HA.22 mothers completed the cross over design; 14 expressed a preference for the HA formula and only 8 f o r NAN.W e cannot therefore confirm that the hypoallergenic milk (HA) improves sleep in a group of sleep disturbed infants. arrd near infixed spectroscopy (NIRS) on 11 cxcasrons in 9 infants (4 girls and 5 boys). The median (range) gestational age was 27 (26-29) weeks and portnatal age was 3 (1-10) days. All infants were receivirig tnech;tnical velitilation ;tnd cranial ul~rasound or autopsy revcalcd ~h;tt whtle I infant had no evidence of cerebral injury. 3 inhnts had intraparenchymal lesioris. ;rnd 5 had intraventricular haemorrhage; 6 infants died. In each study one estimation of CBF by ll'Xe w;i> .~ttcnrpled, he measurement was technically inadequate in 2 cases. Wtthtin 1-9 (nredian 5 ) hours 3-8 estirnalions by NIKS were made. 26/61 riie;tsurenierits wcre technically inadequate, but at Irast 2 were possible in every inl'nm. Comprrisons were thus possible on 9 occasions. I3'Xc tneasurernents r;tnged fro111 4.0-13.2 nil 100g 'min ' and mean NIKS measurements ranged from 8.b-20.3 1ril1IM)g 'rnin l. The nic;rn difference between the methods was 2.3, and tile I r r r i i~~ of itgreelilcnt were -5.0 10 +9.7 nl11Wg 'min 1. Considering the different principles involved ;rnd tlie time gap between estimalions, this sludy rhows reawnable ajireeriient bctwcerl the r~iethtxls. ESTIMATING CEREBRAL BLOOD FLOW IN NEWBORN INFANTS: COMPARISON OF NEAR INFRAREDSPECTROSCOPY AND "'XE-CLEARANCE. 14 L i s e l o t t e Skov. O l e P r v d s a n d G . G r e i s e n D e p a r t m e n t o f N e o n a t o l o g y , R i g s h o s p i t a l e t , --Copenhagen, Denmark.A new method o f m e a s u r i n g c e r e b r a l b l o o d f l o w i n newborn i n f a n t s b y mean o f n e a r i n f r a r e d s p e c t r o s c o p y ( C B F n i r s ) was compared w i t h t h e i n t r a v e n o u s "'Xe c l e a r a n c e t e c h n i q u e (CBFxe). F o r t y C~F n i r s measurements w e r e o b t a i n e d d u r i n g 1 9 '"Xe m e a s u r e m e n t s i n 1 6 i n f a n t s . The t e s t -r e t e ...