No abstract

Body temperature during treadmill running was studied in six dogs at seven different grades from 0–22 degrees of inclination. The replicate variability in the work rectal, skin and fur temperature was ±0.5℉, ±1.4℉ and ±1.3℉, respectively. At grades up to 12 degrees of inclination there is a prolonged steady state in the rectal temperature. At higher grades there is a progressive increase in rectal temperature with running time. Body surface temperatures show little affect at the lower grades. At higher work intensities there is an increase in skin and fur temperature. Maximum heat storage varied from 21.3–41.3 Cal. during short term exhaustive work. This type of calculation is discussed critically. The relationship between rate of rise in rectal temperature and maximum performance time was studied. Without regard to work load a product-moment correlation coefficient of +0.991 was found. Submitted on September 17, 1958

This study investigated the effect of glucocorticoid treatment on survival, on hepatic carbohydrate metabolism, and on levels of hepatic adenine nucleotides in the endotoxin-shocked monkey. Dexamethasone sodium phosphate (DMP) administered either at the time of endotoxin challenge or up to 90 minutes afterward significantly increased the survival rates. Endotoxin administered alone caused profound hypoglycemia and lactic-acidemia, which were alleviated by the administration of DMP. Endotoxin administered alone significantly decreased the hepatic levels of glucose-6-phosphate, fructose-6-phosphate, phospho-enolpyruvate, adenosine triphosphate, adenosine diphosphate, and glycogen; and it significantly increased the hepatic levels of fructose-1,6-diphosphate, lactate, and adenosine mono-phosphate. The administration of DMP at the time of endotoxin challenge maintained the levels of all these metabolites at or near the control levels.

No abstract