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The development of a rapid, simple and accurate analytical method aimed at the detection and quantification of bovine milk in either ovine or caprine milk samples by means of CE-MS analyses of whey proteins with high-ionic strength and presence of acidic running buffer is described. The high-ionic strength buffer was used in order to minimize the problems with the adsorption of the proteins onto the fused-silica capillary wall. The acidic running electrolyte, pH 1.9, was used to support the production of positive ions in electrospray. Highly linear dependences of the ratio of the sum of non-bovine beta-lactoglobulins (ovine or caprine) to the total beta-lactoglobulins in milk mixture (bovine plus ovine or bovine plus caprine) vs. the volume percentage of added bovine milk in ovine (or caprine) milk were obtained. This technique allowed the fast and reliable evaluation of milk adulteration. The amount of bovine milk added into the "non-bovine" ones can be well within the concentration range of 5-95%.

SUMMARY On the basis of clinical, histological and electron microscopical findings, we are proposing that mycosis fungoides can begin in the epidermis. Early involvement of the basal layer of the epidermis is emphasized by the pigmentary changes which herald the onset of about half the cases. The formation of new fibrous tissue above the subepidermal elastic garland and the presence of PAS‐positive globules above the epidermal basement membrane, support the view that the primary change is on the epidermal side of the elastic garland and basement membrane. The predominantly epidermal distribution of the mycosis cell in many early cases suggests that it stems from a cell normally present in the epidermis. The likeliest candidate appears to be the Langerhans cell. A derivation from this cell would explain many puzzling features of mycosis fungoides and in particular the affinity of the mycosis cell for the epidermis.