The article presents the results of analysis and perspectives for the application of Building Information Modeling (BIM) for the selection of effective organizational, technological, and technical solutions in the elimination of the emergency destruction of large-panel buildings as a result of military actions. It has been established that information–mathematical modeling and the usage of a database on typical destructions can improve the work efficiency and safety of the liquidation of emergency destructions of buildings. Moreover, it enables the scaling and identification of the optimal option of emergency stabilization, as well as organizational, technological, and technical actions that have to be urgently taken to prevent the loss of life or collapse of large-panel buildings after massive damage due to shelling and other military actions. Information–mathematical modeling is explored as the key enabler of assessment and decision-making, while typically there is limited access to the survey object and a lack of information about its condition. The case of a large-panel building in Ukraine damaged as a result of a gas explosion was used for the development of the information–mathematical model and for demonstrating the proposed approach. In post-war times, the use of the presented methodology will allow a rapid assessment of the technical condition of buildings and stabilization strategy selection, including the periodicity of monitoring needs and times of repairs.