Gastric cancer is one of the most common lethal malignancy in global and survival mainly depends on prognosis. Sister Chromatid Exchanges (SCEs) assay is a very sensitive method of detecting chromosome fragility. The aim of our study was to determine the chromosomal fragility of gastric cancer patients in vitro. Samples from 32 gastric cancer patients and 12 healthy donors were controlled. Cancer patients lymphocytes' genome is highly fragile as treatment of the cell cultures with MMC caused a statistically significant increase of the mean SCEs frequency (p<0.01). Also, so simultaneous as MMC-induced SCEs frequency of gastric cancer patients was statistically significant (p<0.01) higher compared to the healthy donors. PRI and MI of treated with MMC and untreated lymphocytes of gastric cancer patients were significantly (p<0.01) lower than that of healthy donors. These results suggest that peripheral lymphocyte chromosomes of cancer patients are highly fragile and alkyliotic agents increase their fragility.

Oral cancer is a disease, in the treatment of which the surgical resection of the lesion plays a lead- ing role. Oncological resections in the maxillofacial area create large deficits that affect the functionality and aesthetics of the patient to a large extent, while many times make oncological resection impossible due to their inability to restore. The mandibular deficits are particularly difficult, with the free osteocutaneous fibular flap being the gold standard in repairing large mandibular deficits. In recent years, technology has offered significant as- sistance in the successful restoration of functional and aesthetic disorders through the virtual planning of the operation. In this paper we present a case of oral cancer whose resection and reconstruction with fibula free flap were done after digital design and under the guidance of special cutting guides. To our knowledge, this case of computer-guided reconstruction with FFF represents the first description of such a technique for mandibular reconstruction in the available greek medico-dental literature.