The effect of three different diphenols including 1,1′-thiobis(2-naphthol) (TBN), 2,2′-thiobis(4-methyl phenol) (TBMP) and curcumin (CUR) used in the preparation of sulfonated poly(ether sulfide sulfone) (SPESS) on the mechanical, thermal, and morphological properties of polysulfone (PSf) membranes was studied. In this regard, the morphological characteristics of the nanoporous membranes were explored by developed image analyzer program. Based on the obtained results, PSf membrane modified by SPESS-TBN copolymer showed the best nominal tensile strength in comparison to the other samples with the value of 206 MPa. The optimum real tensile strength with the value of 322 MPa was observed for SPESS-TBMP membrane. It was found that the addition of SPESS, improved the mechanical and thermal properties as well as the performance of membranes. Inspections of scanning electron microscopic images for evaluation of the void properties of membranes revealed that there were 42.3, 8.76, 41.45 and 15.92% of void contents within the structures of neat PSf membrane, SPESS-CUR, SPESS-TBMP and SPESS-TBN, respectively. Moreover, some conceptual relations between morphological and mechanical properties were presented. Finally, the effect of the membrane chemical structure on the mechanical, thermal, and morphological properties was discussed in this study.