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This study demonstrates that, compared with a control population, these patients experience a significant range of auditory disabilities. It is important that clinicians be aware of the impact of such a profound unilateral HL and its potential to affect daily life. Patient counseling prior to surgery is essential, especially in patients whose loss of binaural hearing could constitute a major disability.

SUMMARY BackgroundApproximately 30-40% of patients with Barrett's oesophagus (BE) patients manifest abnormal oesophageal pH profiles despite proton pump inhibitor (PPI) therapy.

want to determine if there is a correlative impact on quality of life. Methods: We have enrolled 20 myeloma participants and 20 control participants, made up largely of caregivers. After informed consent, we perform cognitive testing using selected tests from the NIH Toolbox cognitive domain, administered on an iPad. These tests assess processing speed, working memory, attention, and executive function at four time points: at diagnosis, after initial treatment, four months later or 100 days postautologous stem cell transplant, and nine months after that or one year post-autologous transplant. A quality of life questionnaire (FACT-MM) is also completed at the time of each testing. Current Status: We have collected baseline and secondary time-point data thus far with limited tertiary time-point data. We will continue to study this population longitudinally through early 2020 to complete testing. Preliminary data shows that myeloma patients and controls have similar baseline cognition with mean cognitive scores of 47.8 and 47.9, respectively. Controls appear to improve cognitively at the second testing, with a mean score of 52.7, likely due to practice effect. Myeloma patients stay about the same to slightly worse following induction treatment with a mean cognitive score of 45.6. Interestingly, our quality-of-life data suggests that myeloma patients improve functionally and emotionally following initial treatment, but controls (i.e. caregivers) worsen slightly, both functionally and emotionally, which endorses the growing priority of caregiver support.

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