Human neuroimaging research has transitioned from mapping local effects to developing predictive models of mental events that integrate information distributed across multiple brain systems. Here we review work demonstrating how multivariate predictive models have been utilized to provide quantitative, falsifiable predictions; establish mappings between brain and mind with larger effects than traditional approaches; and help explain how the brain represents mental constructs and processes. Although there is increasing progress toward the first two of these goals, models are only beginning to address the latter objective. By explicitly identifying gaps in knowledge, research programs can move deliberately and programmatically toward the goal of identifying brain representations underlying mental states and processes.

Understanding how emotions are represented neurally is a central aim of affective neuroscience. Despite decades of neuroimaging efforts addressing this question, it remains unclear whether emotions are represented as distinct entities, as predicted by categorical theories, or are constructed from a smaller set of underlying factors, as predicted by dimensional accounts. Here, we capitalize on multivariate statistical approaches and computational modeling to directly evaluate these theoretical perspectives. We elicited discrete emotional states using music and films during functional magnetic resonance imaging scanning. Distinct patterns of neural activation predicted the emotion category of stimuli and tracked subjective experience. Bayesian model comparison revealed that combining dimensional and categorical models of emotion best characterized the information content of activation patterns. Surprisingly, categorical and dimensional aspects of emotion experience captured unique and opposing sources of neural information. These results indicate that diverse emotional states are poorly differentiated by simple models of valence and arousal, and that activity within separable neural systems can be mapped to unique emotion categories.

A central, unresolved problem in affective neuroscience is understanding how emotions are represented in nervous system activity. After prior localization approaches largely failed, researchers began applying multivariate statistical tools to reconceptualize how emotion constructs might be embedded in large-scale brain networks. Findings from pattern analyses of neuroimaging data show that affective dimensions and emotion categories are uniquely represented in the activity of distributed neural systems that span cortical and subcortical regions. Results from multiple-category decoding studies are incompatible with theories postulating that specific emotions emerge from the neural coding of valence and arousal. This ‘new look’ into emotion representation promises to improve and reformulate neurobiological models of affect.

The medial frontal cortex (MFC), including anterior midcingulate cortex, has been linked to multiple psychological domains, including cognitive control, pain, and emotion. However, it is unclear whether this region encodes representations of these domains that are generalizable across studies and subdomains. Additionally, if there are generalizable representations, do they reflect a single underlying process shared across domains, or multiple domain-specific processes? We decomposed multivariate patterns of fMRI activity from 270 participants across 18 studies into study-specific, subdomain-specific, and domain-specific components, and identified latent multivariate representations that generalized across subdomains but were specific to each domain. Pain representations were localized to anterior midcingulate cortex, negative emotion representations to ventromedial prefrontal cortex, and cognitive control representations to portions of the dorsal midcingulate. These findings provide evidence for MFC representations that generalize across studies and subdomains, but are specific to distinct psychological domains rather than reducible to a single underlying process.