Background: Foodborne illness due to the genus Salmonella is one of the major challenges affecting public health worldwide and a threat to socioeconomic activities especially in the developing countries. The present study was carried out to determine the isolation rate and antimicrobial susceptibility profiles of Salmonella species from ruminants slaughtered for human consumption at the two major abattoirs in Ilorin, Kwara State. Methods: Between November, 2019 and February, 2020, a total 500 samples were collected from the two major abattoirs in Ilorin metropolis (cattle, n = 240; goat, n = 260). Salmonella species were isolated and identified using standard bacteriological techniques. The isolates were subjected antimicrobial susceptibility test using Kirby Bauer disk diffusion assay. Results: 20 (4 %) Salmonella isolates were obtained, there was no significant statistical difference between the isolation rates from cattle (3.75 %) and the small ruminant (4.23 %). Varying degree of resistance patterns were obtained with high proportion of the isolates (> 60 %) displaying resistance to penicillin and cephalosporin tested while low resistant phenotypes (5 %) were observed against quinolones. The isolates were pan-susceptible to gentamicin. Conclusion:The study documented multidrug resistant Salmonella isolates from ruminants slaughtered for human consumption. It is recommended that further studies to characterize the isolates will assist in recommending the appropriate control strategies to prevent the transmission of resistant Salmonella strains to human via food chain.