This paper applied the Growth Identification and Facilitation Framework (GIFF), a practical policy tool operationalizing key insights of New Structural Economics, to help policymakers in least developing countries (LDCs) to catching-up by developing feasible and sharply focused policies. In doing so, LDCs are able to identify and unlock their latent comparative advantages to achieve structural transformation. Also, a description of the economic development of Zambia, including agriculture, mining, manufacturing, tourism, import and export of products. Through the comparison with Vietnam, Indonesia, Morocco and Ghana, the paper points out the comparative advantages and development potential of Zambia, and how to transform these comparative advantages into competitive advantages. Based on the analysis of the constraints on the development of Zambia's agriculture, mining, tourism and other industries, the paper proposes some measures for the government to undertake so as to deal with these constraints, in order to promote the development of Zambia.