Two experiments examined the feasibility of psychological assessment using interactive voice response (IVR) technology and the potential sensitivity of such assessments to alcohol and fatigue effects. In Experiment 1, 10subjects performed a l2-min battery of six IVR-administered tasks, Monday through Friday, over 2 weeks. Minimal learning effects were evident during training. Repeated administrations indicated high test-retest reliabilities. In Experiment 2 (double-blind, alcohol/placebo crossover design), 7 subjects were tested every 2 h over a 24-h period during two experimental sessions (peak blood alcohol concentrations = 80 mgldL). Several IVR-administered tasks were sensitive to alcohol impairment, but not as sensitive as laboratory-based measures specifically designed to assess alcohol impairment. Little evidence for fatigue-related impairment was obtained. The results support optimism for the potential to assess psychomotor and cognitive functioning distally via telephony; however, further refinement and validation of the methods are needed.The burgeoning growth of interactive voice response (IVR) applications-automated telephone attendants that accept touch-tone telephone responses-over the past decade attests to the flexibility and utility ofthese systems. IVR applications for bank account status, airline schedules, and college course registration are now commonplace. IVR systems for routing incoming telephone calls to specific departments and individuals and maintaining voice messaging systems are becoming increasingly pervasive in government and business organizations.More recently, research-oriented IVR applications have been developed that integrate computerized interview and longitudinal survey methodologies. In contrast to prior IVR applications designed to provide information and service to callers, these applications have been designed to obtain information from callers in order to address specific behavioral research questions. Computerized applications for obtaining psychiatric diagnostic information have been validated and used for decades (e.g