Drone susceptibility to jamming or spoofing attacks of GPS, RF, Wi-Fi, and operator signals presents a danger to future medical delivery systems. A detection framework capable of sensing attacks on drones could provide the capability for active responses. The identification of interference attacks has applicability in medical delivery, disaster zone relief, and FAA enforcement against illegal jamming activities. A gap exists in the literature for solo or swarm-based drones to identify radio frequency spectrum attacks. Any nondelivery specific function, such as attack sensing, added to a drone involves a weight increase and additional complexity; therefore, the value must exceed the disadvantages. Medical delivery, high-value cargo, and disaster zone applications could present a value proposition which overcomes the additional costs. The paper examines types of attacks against drones and describes a framework for designing an attack detection system with active response capabilities for improving the reliability of delivery and other medical applications.