A simple and rapid method for the determination o f the antibiotic ciprofloxacin by differential pulse po1;irography (DW) has been developed. The changes in the voltammetric behavior o f this drug compound with plI was studied, and the most suitable pH for analytical purposes was found to be pH 8.5. The DPI' behavior o f this compound at this pll exhibited two reduction waves at -1.44 and -1.64 V. The former wave could be used t o determine ciprofloxacin between 5 X lo-' and 3 X l o w 5 M. The method was applied t o the determination o f ciprofloxacin in formulated tablets with a relative standarct deviation o f less t1i:in 0.4%.

We compared hanging mercury drop electrodes (HMDEs) and carbon paste electrodes (CPEs) for the determination by adsorptive stripping voltammetry (AdSV) of the antibiotic ciprofloxacin in urine. The antibiotic compound could be preconcentrated at both electrode surfaces, with carbon paste electrodes yielding a better performance. These electrodes could be used to determine between 6 x lo-' and 4 X M ciprofloxacin in urine. A cleanup procedure (with 81% recovery), utilizing a C,, Sep P a k cartridge, was required to separate ciprofloxacin from the biological matrix prior to adsorptive stripping analysis. The method was applied to the determination of ciprofloxacin in spiked urine samples with a relative standard deviation of 4.1 %.

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