Transition from convective to absolute instability in Rayleigh–Bénard convection in the presence of a uni-directional Poiseuille flow is studied. The evaluation of the long-time behaviour of the Green function in the horizontal plane allows the determination of regions of convective and absolute instability in the Rayleigh–Reynolds number plane as a function of Prandtl number. It is found that the mode reaching zero group velocity at the convective–absolute transition always corresponds to transverse rolls, while the system remains convectively unstable with respect to pure streamwise (longitudinal) rolls for all non-zero Reynolds numbers. Finally, the roll pattern within the entire wave packet and in particular near its centre is elucidated and possible connections between experiments and our findings are discussed.

This analysis of patients treated in clinical practice provides further evidence of the activity of afatinib in ERBB2 mutation-positive NSCLC, and suggests that identification of specific subgroups with certain mutations, such as p.A775_G776ins/YVMA insertion in exon 20, could help optimize outcomes with ErbB2-targeted treatment.