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Through various manifestations, social inappropriateness is frequently the first clinical sign of a neurodegenerative process, especially in AD and bvFTD, years before noticeable impairment on classical neuropsychological assessment and brain atrophy on imaging.

Background A widely held dictum in aging research is that heterogeneity in health increases with age, but the basis for this claim has not been fully investigated. We examined heterogeneity at different ages across health characteristics to describe variation and trends; we investigated the comparative importance of between‐age versus within‐age heterogeneity. Design This was a cohort study. Setting Community‐dwelling older adults. Participants A total of 30,097 adults aged 45 to 86 years, from the Canadian Longitudinal Study on Aging, were included. Measurements Thirty‐four health characteristics in eight domains (physical measures, vital signs, physiological measures, physical performance, function/disability, chronic conditions, frailty, laboratory values) were assessed cross‐sectionally. We used regression models to examine heterogeneity in health characteristics (using absolute deviation) and domains (using effective variance) in relation to age. Comparison between between‐age and within‐age heterogeneity was quantified by estimating the age threshold at which the former exceeds the latter. Results Of the 34 health characteristics, 17 showed increased heterogeneity, 8 decreased, and 9 no association with age. The associations between heterogeneity and age increased generally but were nonlinear for most domains and nonmonotonic for some. We observed peak heterogeneity at approximately 70 years. Between‐age heterogeneity, compared with within‐age heterogeneity, was most important for forced expiratory volume in 1 second and grip strength but varied across characteristics. Conclusion Overall health heterogeneity increases with age but does not uniformly increase across all variables and domains. Heterogeneity in aging reinforces the need for geriatric assessment and personalized care, depending on which health characteristics are assessed, their measurement properties, and their referent group. Our findings suggest further research to develop improved single‐dimension and multidimensional instruments, as well as specific vital and laboratory reference ranges for older adults.