We present a model applicable to ultrasound contrast agent bubbles that takes into account the physical properties of a lipid monolayer coating on a gas microbubble. Three parameters describe the properties of the shell: a buckling radius, the compressibility of the shell, and a break-up shell tension. The model presents an original non-linear behavior at large amplitude oscillations, termed compression-only, induced by the buckling of the lipid monolayer. This prediction is validated by experimental recordings with the high-speed camera Brandaris 128, operated at several millions of frames per second. The effect of aging, or the resultant of repeated acoustic pressure pulses on bubbles, is predicted by the model. It corrects a flaw in the shell elasticity term previously used in the dynamical equation for coated bubbles. The break-up is modeled by a critical shell tension above which gas is directly exposed to water.

The ability of collapsing (cavitating) bubbles to focus and concentrate energy, forces and stresses is at the root of phenomena such as cavitation damage, sonochemistry or sonoluminescence. In a biomedical context, ultrasound-driven microbubbles have been used to enhance contrast in ultrasonic images. The observation of bubble-enhanced sonoporation--acoustically induced rupture of membranes--has also opened up intriguing possibilities for the therapeutic application of sonoporation as an alternative to cell-wall permeation techniques such as electroporation and particle guns. However, these pioneering experiments have not been able to pinpoint the mechanism by which the violently collapsing bubble opens pores or larger holes in membranes. Here we present an experiment in which gentle (linear) bubble oscillations are sufficient to achieve rupture of lipid membranes. In this regime, the bubble dynamics and the ensuing sonoporation can be accurately controlled. The use of microbubbles as focusing agents makes acoustics on the micrometre scale (microacoustics) a viable tool, with possible applications in cell manipulation and cell-wall permeation as well as in microfluidic devices.

International audienceWe depict and analyse the successive steps of atomization of a liquid jet when a fast gas stream blows parallel to its surface. Experiments performed with various liquids in a fast air flow show that the liquid destabilization proceeds from a two-stage mechanism: a shear instability first forms waves on the liquid. The transient acceleration experienced by the liquid suggests that a Rayleigh–Taylor type of instability is triggered at the wave crests, producing liquid ligaments which further stretch in the air stream and break into droplets. The primary wavelength $\lambda\,{\sim}\,\delta (\rho_{1}/\rho_{2})^{1/2}$ is set by the vorticity thickness $\delta$, in the fast air stream and the liquid/gas density ratio $\rho_{1}/\rho_{2}$. The transverse corrugations of the crests have a size $\lperp\,{\sim}\,\delta {\We_{\delta}}^{-1/3} (\rho_{1}/\rho_{2})^{1/3}$, where $\We_{\delta}\,{=}\,\rho_{2}u_{2}^{2}\delta/\sigma$ is the Weber number constructed on the gas velocity $u_{2}$ and liquid surface tension $\sigma$. The ligament dynamics gives rise, after break-up, to a well-defined droplet size distribution whose mean is given by $\lperp$. This distribution bears an exponential tail characteristic of the broad size statistics in airblast sprays