With internationalization becoming an increasing trend in higher education, many universities worldwide have been implementing content and language-integrated learning (CLIL) as an innovative approach to teaching and learning English that helps students compete internationally. Alongside this trend, the advance of digital technologies has offered beneficial use in integrating language and content knowledge. Following the conceptual framework of Hallingda (2013), this systematic review has explored the impact of digital technology use in English education related to the CLIL approach by synthesizing studies on various forms of technologies in supporting different aspects of CLIL. Findings revealed a positive interrelation of digital impact on language use and skills and social collaboration, interaction, and motivation. However, a lack of evidence was found regarding the correlation between using digital technologies and enhancing content knowledge in CLIL. This recommended further research delving into how digital use would assist both language and content teaching and learning so that students at higher educational institutes could effectively access the global world.