Context.In some regions of Australia, the Australian sheep blowfly (Lucilia cuprina) is resistant to some of the pesticides used to control flystrike in sheep. Few pesticide groups are available, so it is important to delay or prevent any increase in resistance. Aims. This study examined some of the assumptions in a previously developed model of pesticide resistance and tested the use of pesticide rotations as a means of limiting blowfly resistance to pesticides. Methods. A model of sheep blowfly pesticide resistance was added to a previous model of sheep blowfly strike, to allow simulation of a range of pesticide management options for control of flystrike in sheep that might avoid increasing pesticide resistance. Key results. The model requires some assumptions of settings that are uncertain, but the effects are not sensitive to a wide range of values for these settings. Resistance may not be obvious for some years after a new product is introduced, but once it has been detected, the frequency of resistance genes will increase rapidly if use of the same pesticide continues. The use of different pesticide groups each year is preferable to continuous use of the same product, but this risks losing efficacy of multiple products rather than one product at a time. However, rotations do provide a longer period of good protection from flystrike before all products used in the rotation fail. The number of years of successful protection against flystrike is extended if there is a fitness disadvantage for resistance to the products used. Conclusions. The model may be useful for examining interactions between genes for resistance to different pesticides and the effect of non-chemical methods of control of flystrike, to extend the useful life of the current range of pesticides. Implications. By the time resistance is detected on a farm, the level of resistance is high and will increase rapidly if the same pesticides continue to be used. Other non-pesticide methods such as breeding sheep for resistance to flystrike may be long-term solutions where resistance has reduced pesticide protection.