Due to their great modularity, ease of implementation, and atom economy, multicomponent reactions (MCRs) are becoming increasingly popular macromolecular engineering tools. In this context, MCRs suitable in polymer synthesis are eagerly searched for. This work demonstrates the potential of the Ugi-three component reaction (Ugi-3CR) for the design of polymers and, in particular, of poly(α-amino amide)s. A series of polymers containing amino and amido groups within their backbone were obtained through a one-pot process by reacting aliphatic or aromatic diamines, diisocyanides, and aldehydes. The impact of temperature, concentration, catalyst loading, and substrates on polymerization efficiency is discussed. A preliminary study on the thermal properties and the solution behavior of these poly(α-amino amide)s was carried out. An aliphatic-rich derivative notably showed some pH-responsiveness in water via protonation−deprotonation of its amino groups.

Interconnected macroporous imidazolium-based monoliths are produced via the modified Radziszewski multicomponent reaction (MCR) applied to triamines under high internal phase emulsion (HIPE) conditions. This straightforward one-pot synthesis combines the efficiency and versatility of MCRs with the ease of implementation of the emulsion templating polymerization process. The characterization of the chemical structure and morphology of the resulting materials confirms the formation of the expected macroporous poly­(ionic liquid)­s (PILs) networks. The promising catalytic activity and recyclability of these porous PIL monoliths are illustrated for the transesterification reaction and the decarboxylation of caffeic acid. In these cases, almost complete conversion is reached while benefiting from the advantages associated with a heterogeneous catalyst.

Polypeptoids, consisting in nitrogen-substituted analogues of polypeptides, have become a real asset in modern sciences especially in the biomedical field. To address the increasing demand for polypeptoid structures with specific...

No abstract