Background Psychobiological processes linking stress and vascular diseases remain poorly understood. The retina and the brain share a common embryonic-diencephalon origin and blood-barrier physiology e.g. ongoing ischemia facilitates S100B release with astrocytic activity and glial-fibrillary-acidic-protein expression (GFAP). However, GFAP decreases revealed astrocyte pathology in the prefrontal cortex of depression/suicide cases; and might be a key mechanism in stress – disease pathways. Methods A chronic emotional stress phenotype independent of age, ethnicity or sex was used to stratify the current prospective cohort (N ​= ​359; aged 46 ​± ​9 years) into Stress (N ​= ​236) and no-Stress groups (N ​= ​123). Prospective data for glia ischemia risk markers were obtained, including 24 ​h BP, fasting S100B, GFAP, HbA 1C and tumor-necrosis-factor-α (TNF-α). At 3-yr follow-up: diastolic-ocular-perfusion-pressure (indicating hypo-perfusion risk) was measured and retinal vessel calibers were quantified from digital images in the mydriatic eye. Results Higher hypertension (75% vs. 16%), diabetes (13% vs. 0%) and retinopathy (57% vs. 45%) prevalence was observed in Stress compared to no-Stress individuals. Stressed individuals had consistently raised S100B, TNF-α, HbA 1C and higher diastolic-ocular-perfusion-pressure, but decreases in GFAP and GFAP:S100B. Furthermore stroke risk markers, arterial narrowing and venous widening were associated with consistently raised S100B, GFAP:S100B (p ​= ​0.060), TNF-α and higher diastolic-ocular-perfusion-pressure [Adj. R 2 0.39–0.41, p ​≤ ​0.05]. No retinal-glia associations were evident in the no-Stress group. Conclusions Retinal-glia ischemia and inflammation was induced by chronic stress. Persistent higher inflammation and S100B with GFAP decreases further reflected stress-induced astrocyte pathology in the human retina. It is recommended to increase awareness on chronic stress and susceptibility for brain ischemia.

Despite the advantages dynamic reconfiguration adds to a system, it only improves system performance if the execution time exceeds the configuration time. As a result, dynamic reconfiguration is only capable of improving the performance of quasi-static applications. In order to improve the performance of dynamic applications, researchers focus on improving the reconfiguration throughput. These approaches are mostly limited by the bus commonly used to connect the configuration controller to the memory, which contributes to the configuration time. A method proposed to ameliorate this overhead is an architecture utilizing localised block RAM (BRAM) connected to the configuration controller to store the configuration bitstream. The aim of this paper is to illustrate the advantages of the proposed architecture, especially for reconfiguring real-time applications. This is done by validating the throughput of the architecture and comparing this to the maximum theoretical throughput of the internal configuration access port (ICAP). It was found that the proposed architecture is capable of reconfiguring an application within a time-frame suitable for real-time reconfiguration. The drawback of this method is that the BRAM is extremely limited and only a discrete set of configurations can be stored. This paper also proposes a method on how this can be mitigated without affecting the throughput.

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